The second act of Patrick Arnold: the chemist who designed The Clear, then invented the ketone supplement industry

In 2011, a University of South Florida researcher called Dominic D'Agostino came to Patrick Arnold with a request. He needed a molecule synthesised. The molecule was a ketone ester, a compound that, taken orally, would metabolise in the body into acetoacetate and beta-hydroxybutyric acid, the two endogenous ketones the body produces when it fully metabolises…

ByJon LipseyMay 13, 20260Comments

TECH Vanguard

Owkin’s Andrea Tassistro on K Pro and the AI drug discovery bottleneck

The AI-drug-discovery sector in 2026 has split into two camps. One camp wants to design new molecules from first principles. The other wants to make existing pharma R&D faster, cheaper and less likely to fail. The first camp gets the magazine covers. The second camp is closer to a working business. Owkin sits firmly in…

ByJon LipseyMay 13, 20260Comments

stacy sims women should lift heavy weights

TRAINING

Will lifting weights make women bulky? Dr Stacy Sims on why every woman should lift heavy

The fear that lifting weights will make women bulky is the single most damaging idea in women's fitness. Not because it's the most obviously wrong — there are wronger ideas in the field. But because it's the most consequential. The women who avoid the weights room because they're worried about getting bulky lose access to…

ByJoe WarnerMay 12, 20260Comments

BUSINESS Vanguard

Rick Adams: the Olympic insider leading the Enhanced Games

If you had to design the person you'd want on your side if you were an athlete about to walk into the most scrutinised sporting arenas of the modern era, you'd probably end up with someone who looked a lot like Rick Adams. Six Olympic Games. Fourteen years inside the American Olympic machine. Former Chief…

ByJon LipseyApril 21, 20260Comments

HEALTH Explainer

What is epigenetic reprogramming and why does it matter?

Epigenetic reprogramming is a biological process that modifies how genes are expressed without altering the underlying DNA sequence, with the goal of restoring cells to a more youthful functional state. At its core, the concept is simple but far-reaching: ageing is not only driven by genetic mutations, but by accumulated changes in how genes are…

ByJon LipseyApril 15, 20260Comments

BUSINESS Vanguard

The Enhanced Games Are Here. Sport Will Never Be the Same.

Five and a half weeks out from the inaugural Enhanced Games, world records are already being broken. Earlier this month Chilean weightlifter Arley Méndez Pérez snatched 182kg in training at 88kg bodyweight, 5kg heavier than the current official world record. That follows Greek Olympic swimmer Kristian Gkolomeev, who last year eclipsed the standing 50m freestyle…

ByJon LipseyApril 15, 20260Comments

BUSINESS

Marriott partners with Lefay to launch a dedicated wellness brand

Marriott International has entered a joint venture with Italian wellness brand Lefay, bringing the company into its global portfolio as its first brand dedicated exclusively to luxury wellness. The deal combines Lefay’s existing brand, intellectual property, and operating model with Marriott’s global scale, development infrastructure, and loyalty ecosystem. Lefay currently operates two resorts in Italy…

ByJon LipseyApril 13, 20260Comments

TECH

Function acquires Getlabs to expand at-home diagnostics

Function Health has acquired Getlabs, a mobile healthcare platform that dispatches licensed professionals to collect blood samples at a patient’s home, office, or other location. The integration introduces a new option for Function members: either visit one of more than 2,000 lab locations or schedule a home blood draw. The diagnostic process, lab panels, and…

ByJon LipseyApril 12, 20260Comments

MIND Vanguard

The race to copy your brain before AI replaces you

Christian Larsen does not hedge when the conversation turns to AI. If a superintelligent AI “species” emerges, one that is faster, more capable and operating at a fundamentally different level of capacity, he believes the outcome is already decided. “There’s no question that they will have the upper hand,” he says. Not in ten years.…

ByJon LipseyApril 2, 20260Comments

HEALTH Explainer

What is biological dentistry?

Biological dentistry treats the mouth as part of the whole body rather than a separate repair site. In practice that means metal-free restorations, protective protocols when removing existing metalwork, and treating chronic dental infection as a possible contributor to illness elsewhere in the body. Parts of the approach are now mainstream: the EU banned dental…

ByJon LipseyMarch 24, 20260Comments

Newsletter

Sign Up to Our Newsletter