Longevity has stopped being a Silicon Valley curiosity. Over the past four years, the field has crossed the line from speculative science to institutional industry. Tech billionaires have poured billions into it. Sovereign wealth funds have arrived. The first human trial of partial cellular reprogramming starts this year, with FDA clearance already in hand. A…
During a Zoom call on the 26th January 2024, Aron D'Souza, founder of the Enhanced Games, revealed something to me that he asked me to keep to myself.
The Enhanced Games, which takes place in Las Vegas on Sunday, is the world's first sporting competition in which athletes are permitted to use performance-enhancing substances banned…
In August 1998, an Associated Press reporter spotted a brown bottle in Mark McGwire's locker at Busch Stadium. The bottle was androstenedione. McGwire was in the middle of the home-run chase that would end with him at 70 and Sammy Sosa at 66. He confirmed to reporters he had been taking the supplement for over…
In 2011, a University of South Florida researcher called Dominic D'Agostino came to Patrick Arnold with a request. He needed a molecule synthesised. The molecule was a ketone ester, a compound that, taken orally, would metabolise in the body into acetoacetate and beta-hydroxybutyric acid, the two endogenous ketones the body produces when it fully metabolises…
The chemist who designed the most consequential undetectable steroid in the history of professional sport spent the last decade of his life trying to build something else. A ketone ester for a Navy-funded research lab. BHB salts. NAD precursors. A longevity formula he was developing with an old partner. A gram of NMN every morning.…
The AI-drug-discovery sector in 2026 has split into two camps. One camp wants to design new molecules from first principles. The other wants to make existing pharma R&D faster, cheaper and less likely to fail. The first camp gets the magazine covers. The second camp is closer to a working business.
Owkin sits firmly in…
Bret Kovacs commutes several hours a day into New York. Most mornings he stands on the same train platform looking at the same set of ads. Hims, Ro and the rotating cast of consumer health brands competing for the same eye-line. The visual grammar is consistent: vials, syringes and pills. Sometimes a model. Sometimes a…
In July 2021, Carole Hooven went on Fox & Friends to discuss an article in The Free Press about medical schools moving away from the words male and female. She defended the terms. She said biologists use them because they are scientifically accurate, and that respecting people's gender identities does not require abandoning scientific language.…
For most of the time the medical community has been paying attention to relative energy deficiency in sport, the condition has been understood as a women's problem. The original framework was the female athlete triad, identified in the 1990s — the cluster of disordered eating, menstrual dysfunction and low bone mineral density that emerged in…
The oral contraceptive pill is one of the most widely used pharmaceuticals in human history. Tens of millions of women take it daily, mostly for contraception, sometimes for symptom management around heavy menstrual bleeding, polycystic ovary syndrome or endometriosis. The cultural assumption that travels with it — that the synthetic hormones it delivers are functionally…



