Selective Androgen Receptor Modulators, or SARMs, have emerged as a popular alternative to anabolic steroids, promising muscle growth and fat loss without the severe side effects associated with steroids.

Originally developed for medical purposes, including treating muscle wasting and osteoporosis SARMs, like many other pharmaceutical drugs, compounds and peptides, have inevitably found their way into the fitness and bodybuilding world for their physique- and performance-improving properties.

The primary advantage SARMs, such as S23, offer is their ability to selectively target androgen receptors in just muscle and bone tissues, potentially offering the benefits of steroids with fewer risks. However, their safety, legality, and long-term effects remain hotly contested. Here’s what you need to know.

What are SARMs?

SARMs, or Selective Androgen Receptor Modulators, are a class of therapeutic compounds that have similar properties to anabolic steroids but with reduced androgenic (male characteristic) properties. Unlike steroids, SARMs selectively target and activate androgen receptors in specific tissues, such as muscles and bones, while sparing other tissues like the liver, heart and prostate.

How do SARMs work?

They bind to androgen receptors in muscle and bone tissues, stimulating protein synthesis and muscle growth. This targeted action can help increase muscle mass, improve strength, and enhance physical performance without the widespread side effects typically seen with steroids. Products such as Ostarine (MK-2866) and Ligandrol (LGD-4033) are popular for their anabolic effects.

Why do people take Selective Androgen Receptor Modulators?

They are used primarily to enhance muscle growth, increase strength and improve athletic performance. They are particularly appealing to bodybuilders, athletes, and fitness enthusiasts looking for an edge without the significant side effects of anabolic steroids. Some also use them for their potential to aid fat loss and improve muscle definition.

Do SARMs have the same side-effects as steroids?

SARMs are designed to minimise the androgenic side effects seen with steroids, such as hair loss, acne, and prostate enlargement. However, they can still cause significant hormonal disruptions, including testosterone suppression and potential liver damage. The side effects can vary depending on the specific compound and exact dosage used.

Are Selective Androgen Receptor Modulators dangerous?

While marketed as a safer alternative to steroids, SARMs are not without risks. Studies have shown that they can cause a range of side effects, including liver toxicity, hormone imbalances, and cardiovascular issues. Long-term effects are still largely unknown due to the lack of extensive human trials. According to research published in the Journal of the American Medical Association, their unregulated nature can lead to contamination and mislabeling, increasing potential health risks.

Are SARMs legal?

The legality varies by country. In the UK and US, SARMs are not approved for human consumption and are considered research chemicals. They are banned by most sports organisations, including the World Anti-Doping Agency (WADA). Despite this, they’re often sold online and marketed as dietary supplements, which can be misleading.

Where can you buy SARMs?

They’re commonly available through online vendors and some supplement shops. However, due to their unregulated status, their quality and purity can be questionable. Many products may be mislabeled or contaminated, posing additional health risks. It is crucial to exercise caution and conduct thorough research if considering their use.