Eli Lilly advances retatrutide to Phase 3 to expand next-generation multi-hormone obesity therapeutics

Eli Lilly is progressing its experimental obesity and type 2 diabetes drug retatrutide into Phase 3 trials, following late-stage data showing significant weight loss and metabolic improvements. Retatrutide belongs to a new class of drugs known as triple agonists, targeting three key metabolic pathways simultaneously. In earlier trials, the drug demonstrated weight loss outcomes exceeding…

ByJon LipseyMarch 26, 20260Comments

NUTRITION Explainer

What is metabolic confusion?

In the restless world of dieting, metabolic confusion has become a hot topic. Unlike traditional approaches to eating that stick to consistent calorie restrictions, metabolic confusion introduces flexibility by alternating between high-calorie and low-calorie days. The theory? Keep your metabolism guessing, and you’ll avoid weight-loss plateaus. But does it really work and should you try…

ByJon LipseyJanuary 14, 20260Comments

HEALTH Explainer

What is your metabolic age and how do you calculate it?

You're familiar with your chronological age, but there’s another measure that could be even more relevant when it comes to your health—your metabolic age. This lesser-known metric gives you an idea of how your body is aging on the inside, and it’s often a better indicator of overall health than the number of candles on…

ByJon LipseyDecember 13, 20250Comments

Ozempic weight loss drug obesity diabetes pharma

HEALTH Explainer

What is Ozempic and how do weight-loss drugs work?

In the war against two of the world's most pressing health challenges - obesity and type-2 diabetes - a major new offensive has been opened by the discovery of a new generation of weight-loss drugs. Of these new pharmaceutical interventions Ozempic, the brand name of manufacturer Novo Nordisk’s semaglutide formulation, has attracted the most interest…

ByJoe WarnerMay 20, 20240Comments

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HEALTH Explainer

Should you be worried about blood sugar spikes?

If you follow any health and fitness accounts on social media it can feel like everyone is talking about their blood sugar levels. Thanks to the rapid emergence of continuous glucose monitors (CGMs) - in part thanks to the near non-stop promotion by Dr Tim Spector of his ZOE personalised nutrition app - which give…

ByJoe WarnerMay 20, 20240Comments

Stacy Sims cardio fasted fed weight training women fitness health

TRAINING Upgrade

Dr Stacy Sims: Why women should never exercise on an empty stomach

Dr Stacy Sims, PhD Dr Stacy Sims, PhD, is an exercise physiologist and nutrition scientist who aims to revolutionise exercise nutrition and performance for women. She has published more than 70 peer-reviewed papers, and authored female-focused performance optimisation books, Roar, and Next Level, which challenge the existing dogma around exercise, nutrition, and health for women.…

ByJoe WarnerMay 18, 20240Comments

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TRAINING Upgrade

Dr Stacy Sims: Should women do ice baths after exercise?

Dr Stacy Sims, PhD Dr Stacy Sims, PhD, is an exercise physiologist and nutrition scientist who aims to revolutionise exercise nutrition and performance for women. She has published more than 70 peer-reviewed papers, and authored female-focused performance optimisation books, Roar, and Next Level, which challenge the existing dogma around exercise, nutrition, and health for women.…

ByJoe WarnerApril 25, 20240Comments

Dr Michael Mosley daily mail health exercise story

TRAINING Healthy Sceptic

Why you can’t trust this media report about exercise and fat loss

The headline Dr Michael Mosley: Why running more won't help you to lose weight... and nor will it make you live longer - that's just one of the many common myths about exercise The source Daily Mail online What the story said Author and resident BBC medic, Dr Michael Mosley, used a recent study to…

ByJoe HalsteadJanuary 1, 20241Comment

Health at every size obesity plus size models

INVESTIGATIONS Obesity crisis

Is the Health At Every Size movement harming the people it’s trying to help?

Browse ‘health at every size’ on social media and you will soon see why this weight-inclusive movement attracts such frenzied debate. There is certainly much to admire about an approach which rejects weight-loss goals; invites a broader view of health; promotes enjoyable physical movement for people of all sizes; fights weight stigma; champions inclusive access…

ByMark BaileySeptember 1, 20230Comments

Will the carnivore diet harm your health

NUTRITION

The carnivore diet: your complete guide

The carnivore diet has emerged as a topic of significant interest and debate among nutritionists, scientists, and health enthusiasts alike. This approach to eating, predicated on the consumption of animal products to the exclusion of everything else, presents a return to a more primal form of eating. But why should this matter to you? Beyond…

ByJon LipseySeptember 1, 20220Comments

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