Eli Lilly advances retatrutide to Phase 3 to expand next-generation multi-hormone obesity therapeutics

Eli Lilly is progressing its experimental obesity and type 2 diabetes drug retatrutide into Phase 3 trials, following late-stage data showing significant weight loss and metabolic improvements. Retatrutide belongs to a new class of drugs known as triple agonists, targeting three key metabolic pathways simultaneously. In earlier trials, the drug demonstrated weight loss outcomes exceeding…

March 26, 20260Comments

ByJon Lipsey

NUTRITION

Fasting-mimicking therapy shows metabolic benefit in clinical trial

A clinical trial examining a fasting-mimicking intervention has reported improvements in several metabolic markers associated with ageing and chronic disease risk, adding to the growing body of research exploring fasting-based nutritional strategies. The study evaluated the metabolic impact of a structured fasting-mimicking protocol designed to simulate many physiological effects of fasting while allowing limited nutrient…

March 22, 20260Comments

ByJon Lipsey

NUTRITION Explainer

What is a fasting-mimicking diet and how does it influence metabolic and ageing pathways?

For decades, fasting has been studied as one of the most powerful metabolic interventions affecting health and longevity. In laboratory animals, calorie restriction and fasting can extend lifespan, improve metabolic resilience, and influence cellular repair mechanisms. The challenge has always been practical: prolonged fasting is difficult to maintain. The fasting-mimicking diet (FMD) emerged as an…

March 17, 20260Comments

ByJon Lipsey

HEALTH Obesity crisis

Metabolic ill health will cost the global economy trillions

McKinsey Health Institute recently released a 59-page report on global metabolic health — and the numbers are impossible to ignore. Around 900 million adults worldwide are obese, and more than 20 chronic diseases, from diabetes to dementia, are directly linked to obesity. The economic impact is equally severe: $2.76 trillion in GDP could be wiped…

February 1, 20260Comments

ByJon Lipsey

NUTRITION Explainer

What is metabolic confusion?

In the restless world of dieting, metabolic confusion has become a hot topic. Unlike traditional approaches to eating that stick to consistent calorie restrictions, metabolic confusion introduces flexibility by alternating between high-calorie and low-calorie days. The theory? Keep your metabolism guessing, and you’ll avoid weight-loss plateaus. But does it really work and should you try…

January 14, 20260Comments

ByJon Lipsey

Insulin and health metabolism and diabetes

HEALTH Explainer

Decoding insulin: A deep dive into its role in health and fitness

Insulin, a hormone synthesised by the pancreas, is essential in regulating the body's metabolism of carbohydrates, fats, and proteins. When we consume food, particularly carbohydrates, they are broken down into glucose, which enters the bloodstream. Insulin facilitates the cells' uptake of glucose, converting it into energy. This process reduces blood glucose levels, ensuring they remain…

September 5, 20230Comments

ByJon Lipsey

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